LL-37

99% Pure | Made in USA | Multidose

LL-37 is a naturally occurring antimicrobial peptide and the only cathelicidin-derived peptide found in humans. Composed of 37 amino acid residues, LL-37 plays a central role in the innate immune system and has been extensively studied for its broad-spectrum antimicrobial, immunomodulatory, and wound-healing properties.

As a key component of the body’s first line of defense, LL-37 is expressed in various immune cells, epithelial surfaces, and barrier tissues. Its multifunctional nature has made it a subject of significant research interest in infection biology, inflammatory regulation, and tissue repair.

Mechanism of Action

LL-37 exerts its effects through multiple mechanisms, primarily by disrupting microbial membranes and modulating host immune responses. Its amphipathic alpha-helical structure allows it to interact with negatively charged microbial surfaces, leading to membrane destabilization. Key actions include:

• Direct disruption of bacterial, viral, and fungal membranes
• Neutralization of lipopolysaccharide (LPS) and reduction of endotoxin activity
• Recruitment and activation of immune cells to sites of infection
• Modulation of pro-inflammatory and anti-inflammatory cytokine signaling

This dual antimicrobial and immunomodulatory mechanism positions LL-37 as a versatile research tool for studying innate immunity, host defense, and inflammation.

Antimicrobial & Infection Research

LL-37 has demonstrated broad-spectrum antimicrobial activity in numerous preclinical studies. Research findings include:

• Effective activity against gram-positive and gram-negative bacteria
• Antiviral properties including inhibition of viral entry and replication
• Antifungal activity against common pathogenic fungi
• Ability to disrupt biofilm formation and enhance antibiotic efficacy

These properties make LL-37 a highly relevant compound in research addressing antibiotic resistance, biofilm-associated infections, and novel antimicrobial strategies.

Wound Healing & Tissue Repair Research

Research indicates that LL-37 plays a significant role in wound healing and tissue regeneration. In preclinical models:

• Enhanced keratinocyte migration and proliferation at wound sites
• Promotion of angiogenesis and new blood vessel formation
• Accelerated wound closure and improved tissue remodeling
• Modulation of inflammatory responses to support optimal healing

These findings highlight the compound’s relevance in research focused on chronic wound management, tissue engineering, and regenerative medicine.

Key Research Focus Areas:

• Innate immunity and cathelicidin-mediated host defense
• Broad-spectrum antimicrobial activity and biofilm disruption
• Immunomodulation and inflammatory cytokine regulation
• Wound healing, tissue repair, and angiogenesis
• Antibiotic resistance and novel antimicrobial strategies
• Epithelial barrier function and mucosal immunity

Quality & Compliance:

• ≥99% purity (HPLC & Mass Spectrometry verified)
• Manufactured in the USA
• Third-party tested by independent U.S. laboratories
• Sterile, research-grade formulation
• Multidose format for controlled research applications

Important Notice:

For research purposes only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease.