5-Amino-1MQ

99% Pure | Made in USA | Multidose

5-Amino-1MQ (5-Amino-1-Methylquinolinium) is a small-molecule research compound extensively studied for its role as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme closely linked to metabolic regulation, energy balance, and cellular aging pathways.

NNMT plays a critical role in regulating nicotinamide metabolism and acts as a key modulator of NAD⁺ availability within cells. Elevated NNMT activity has been associated with increased fat accumulation, reduced metabolic efficiency, and impaired cellular energy production. By selectively inhibiting NNMT, 5-Amino-1MQ allows researchers to investigate how preserving NAD⁺ levels may influence mitochondrial function, metabolic output, and cellular resilience.

Mechanism of Action

5-Amino-1MQ binds to the active site of NNMT, effectively blocking the methylation of nicotinamide and preventing its conversion into 1-methylnicotinamide (MNA). This inhibition shifts cellular metabolism by:

• Increasing intracellular NAD⁺ availability
• Enhancing mitochondrial bioenergetics
• Supporting sirtuin and energy-regulating enzyme activity
• Reducing lipogenesis (fat storage signaling pathways)

This mechanism positions 5-Amino-1MQ as a powerful tool in research exploring metabolic efficiency, energy production, and longevity pathways.

Metabolic & Body Composition Research

Preclinical research has demonstrated that NNMT inhibition via 5-Amino-1MQ can significantly influence fat metabolism and body composition. In diet-induced obesity models:

• Body weight reduction was observed without changes in food intake
• White adipose tissue mass decreased by ~35%
• Adipocyte size and volume were significantly reduced
• Total cholesterol levels improved toward normal ranges

These findings suggest that the compound’s effects are driven by metabolic reprogramming rather than appetite suppression, making it highly relevant for research into lipid metabolism and energy utilization.

NAD⁺, Mitochondrial Function & Longevity Research

By preserving NAD⁺—a critical coenzyme required for cellular energy production, DNA repair, and mitochondrial function—5-Amino-1MQ is widely studied in models of aging and cellular decline.

Research indicates that NNMT inhibition:

• Increases NAD⁺ levels within cells
• Enhances mitochondrial efficiency and ATP production
• Supports oxidative stress resistance
• Promotes improved cellular repair and resilience

This has led to growing interest in 5-Amino-1MQ within longevity-focused research exploring age-related metabolic decline and mitochondrial dysfunction.

Muscle Performance & Energy Output Research

Emerging studies suggest that 5-Amino-1MQ may also influence muscle physiology and performance:

• Improved muscle strength and endurance observed in aged models
• Reduction in intramuscular fat accumulation
• Potential synergy with exercise-related pathways
• Enhanced energy utilization through NAD⁺-dependent mechanisms

These findings highlight its relevance in research focused on physical performance, recovery, and age-related muscle decline.

Key Research Focus Areas:

• NNMT inhibition and metabolic regulation
• NAD⁺ preservation and mitochondrial function
• Fat metabolism and adipocyte signaling pathways
• Insulin sensitivity and glucose metabolism research
• Cellular energy production and oxidative stress reduction
• Aging, longevity, and metabolic resilience

Quality & Compliance:

• ≥99% purity (HPLC & Mass Spectrometry verified)
• Manufactured in the USA
• Third-party tested by independent U.S. laboratories
• Sterile, research-grade formulation
• Multidose format for controlled research applications

Important Notice:

For research purposes only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease.